The project aims to find a novel treatment for pycnodysostosis, a genetic lysosomal disease. MIMIC-KeY is divided in two main objectives:
1) Key understanding: We aim to learn from nature and identify the key molecules at the surface of natural EVs (derived from cancer cells), that enable their natural homing capability and their content transfer to the target recipient cells.

2) MIMIC: We aim to synthetically produce new artificial EV-mimics, with the minimum requirement for cell recognition and cargo transfer, composed of: artificial lipid bilayers/functional proteins, triggerable porous organosilica nanocapsules and soft nanogels, loaded with the desired therapeutic cargo (enzyme Cathepsin K, CTSK).